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Third party research (Regenerative)

Third party research
(Interstitium and Telocytes)

Third party research
(Technology Advancements)

Third party research (Fascia and Connective Tissue)

  • Yang J, Chen Z, Pan D, Li H, Shen J. Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes Combined Pluronic F127 Hydrogel Promote Chronic Diabetic Wound Healing and Complete Skin Regeneration. Int J Nanomedicine. 2020 Aug 11;15:5911-5926. doi: 10.2147/IJN.S249129. PMID: 32848396; PMCID: PMC7429232.
  • Zhu Y, Wang Y, Jia Y, Xu J, Chai Y. Roxadustat promotes angiogenesis through HIF-1α/VEGF/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats. Wound Repair Regen. 2019 Jul;27(4):324-334. doi: 10.1111/wrr.12708. Epub 2019 Feb 28. PMID: 30817065.
  • Huang X, Liang P, Jiang B, Zhang P, Yu W, Duan M, Guo L, Cui X, Huang M, Huang X. Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis. Life Sci. 2020 Oct 15;259:118246. doi: 10.1016/j.lfs.2020.118246. Epub 2020 Aug 10. PMID: 32791151.
  • Bullard JD, Lei J, Lim JJ, Massee M, Fallon AM, Koob TJ. Evaluation of dehydrated human umbilical cord biological properties for wound care and soft tissue healing. J Biomed Mater Res B Appl Biomater. 2019 May;107(4):1035-1046. doi: 10.1002/jbm.b.34196. Epub 2018 Sep 10. PMID: 30199609; PMCID: PMC6585686.
  • Hsieh L, Nugent D. Factor XIII deficiency. Haemophilia. 2008 Nov;14(6):1190-200. doi: 10.1111/j.1365-2516.2008.01857.x. PMID: 19141159.
  • Gaebel R, Furlani D, Sorg H, Polchow B, Frank J, Bieback K, Wang W, Klopsch C, Ong LL, Li W, Ma N, Steinhoff G. Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration. PLoS One. 2011 Feb 10;6(2):e15652. doi: 10.1371/journal.pone.0015652. PMID: 21347366; PMCID: PMC3037376.
  • Yan ZJ, Wang D, Ye Z, Fan T, Wu G, Deng L, Yang L, Li B, Liu J, Ma T, Dong C, Li ZT, Xiao L, Wang Y, Wang W, Hou JL. Artificial Aquaporin That Restores Wound Healing of Impaired Cells. J Am Chem Soc. 2020 Sep 16;142(37):15638-15643. doi: 10.1021/jacs.0c00601. Epub 2020 Sep 3. PMID: 32876439.
  • Mouritzen MV, Andrea A, Qvist K, Poulsen SS, Jenssen H. Immunomodulatory potential of Nisin A with application in wound healing. Wound Repair Regen. 2019 Nov;27(6):650-660. doi: 10.1111/wrr.12743. Epub 2019 Jul 9. PMID: 31287619.
  • Wang TY, Wang W, Li FF, Chen YC, Jiang D, Chen YD, Yang H, Liu L, Lu M, Sun JS, Gu DM, Wang J, Wang AP. Maggot excretions/secretions promote diabetic wound angiogenesis via miR18a/19a – TSP-1 axis. Diabetes Res Clin Pract. 2020 Jul;165:108140. doi: 10.1016/j.diabres.2020.108140. Epub 2020 Apr 8. PMID: 32277954.
  • Feng Y, Zhan F, Zhong Y, Tan B. Effects of human umbilical cord mesenchymal stem cells derived from exosomes on migration ability of endometrial glandular epithelial cells. Mol Med Rep. 2020 Aug;22(2):715-722. doi: 10.3892/mmr.2020.11137. Epub 2020 May 7. PMID: 32626977; PMCID: PMC7339775.
  • Structure and Distribution of an Unrecognized Interstitium in Human Tissues from Scientific Reportshttps://www.nature.com/articles/s41598-018-23062-6
  • Telocytes in human term placenta: morphology and phenotype from Cells Tissues Organshttps://www.ncbi.nlm.nih.gov/pubmed/20664249
  • Telocytes revisited from Biomol Conceptshttps://www.ncbi.nlm.nih.gov/pubmed/25367617
  • Quantitative Analysis of Musculoskeletal Ultrasound: Techniques and Clinical Applications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429913/
  • Accuracy and performance of a new handheld ultrasound machinewith wireless system https://www.nature.com/articles/s41598-019-51160-6
First party research
Third party research
Adhesive Capsulitis
  1. 1. Thawing the Ice: The Clinical Diagnosis and Effective Management of Adhesive Capsulitis:

    Sullivan, Erin; Bhandari-Young, Solomon; Kamat, Aimee; Best, Thomas M.. Orthopaedic Nursing 44(5):p 269-277, September/October 2025. | DOI: 10.1097/NOR.0000000000001149
  2. 2. A Novel Treatment for Combined Adhesive Capsulitis and Glenohumeral Osteoarthritis – Case Study: RELIEF® Treatment:

    Sullivan, Erin; Movassaghi, Babak; Kamat, Aimee; Gautam, Abhinav; Best, Thomas M.. – Case Study: RELIEF® Treatment. Orthopaedic Nursing 44(3):p 167-174, May/June 2025. | DOI: 10.1097/NOR.0000000000001115
Regenerative
Interstitium & Telocytes
Technology Advancements
Fascia & Connective Tissue
  1. Yang J, Chen Z, Pan D, Li H, Shen J. Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes Combined Pluronic F127 HydrogelPromote Chronic Diabetic Wound Healing and Complete Skin Regeneration. Int J Nanomedicine. 2020 Aug 11;15:5911-5926. doi: 10.2147/IJN.S249129. PMID: 32848396; PMCID: PMC7429232.

  2. Zhu Y, Wang Y, Jia Y, Xu J, Chai Y. Roxadustat promotes angiogenesis through HIF-1α/VEGF/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats. Wound Repair Regen. 2019 Jul;27(4):324-334. doi: 10.1111/wrr.12708. Epub 2019 Feb 28. PMID: 30817065.

  3. Huang X, Liang P, Jiang B, Zhang P, Yu W, Duan M, Guo L, Cui X, Huang M, Huang X. Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis. Life Sci. 2020 Oct 15;259:118246. doi: 10.1016/j.lfs.2020.118246. Epub 2020 Aug 10. PMID: 32791151.

  4. Bullard JD, Lei J, Lim JJ, Massee M, Fallon AM, Koob TJ. Evaluation of dehydrated human umbilical cord biological properties for wound care and soft tissue healing. J Biomed Mater Res B Appl Biomater. 2019 May;107(4):1035-1046. doi: 10.1002/jbm.b.34196. Epub 2018 Sep 10. PMID: 30199609; PMCID: PMC6585686.

  5. Hsieh L, Nugent D. Factor XIII deficiency. Haemophilia. 2008 Nov;14(6):1190-200. doi: 10.1111/j.1365-2516.2008.01857.x. PMID: 19141159.

  6. Gaebel R, Furlani D, Sorg H, Polchow B, Frank J, Bieback K, Wang W, Klopsch C, Ong LL, Li W, Ma N, Steinhoff G. Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration. PLoS One. 2011 Feb 10;6(2):e15652. doi: 10.1371/journal.pone.0015652. PMID: 21347366; PMCID: PMC3037376.

  7. Yan ZJ, Wang D, Ye Z, Fan T, Wu G, Deng L, Yang L, Li B, Liu J, Ma T, Dong C, Li ZT, Xiao L, Wang Y, Wang W, Hou JL. Artificial Aquaporin That Restores Wound Healing of Impaired Cells. J Am Chem Soc. 2020 Sep 16;142(37):15638-15643. doi: 10.1021/jacs.0c00601. Epub 2020 Sep 3. PMID: 32876439.

  8. Mouritzen MV, Andrea A, Qvist K, Poulsen SS, Jenssen H. Immunomodulatory potential of Nisin A with application in wound healing. Wound Repair Regen. 2019 Nov;27(6):650-660. doi: 10.1111/wrr.12743. Epub 2019 Jul 9. PMID: 31287619.

  9. Wang TY, Wang W, Li FF, Chen YC, Jiang D, Chen YD, Yang H, Liu L, Lu M, Sun JS, Gu DM, Wang J, Wang AP. Maggot excretions/secretions promote diabetic wound angiogenesis via miR18a/19a – TSP-1 axis. Diabetes Res Clin Pract. 2020 Jul;165:108140. doi: 10.1016/j.diabres.2020.108140. Epub 2020 Apr 8. PMID: 32277954.

  10. Feng Y, Zhan F, Zhong Y, Tan B. Effects of human umbilical cord mesenchymal stem cells derived from exosomes on migration ability of endometrial glandular epithelial cells. Mol Med Rep. 2020 Aug;22(2):715-722. doi: 10.3892/mmr.2020.11137. Epub 2020 May 7. PMID: 32626977; PMCID: PMC7339775.

  11. Qi WY, Gao XM, Ma ZY, Xia CL, Xu HM. Antiangiogenic activity of terpenoids from Euphorbia neriifolia Linn. Bioorg Chem. 2020 Mar;96:103536. doi: 10.1016/j.bioorg.2019.103536. Epub 2019 Dec 28. PMID: 31972463.

  12. Ma J, Zhao Y, Sun L, Sun X, Zhao X, Sun X, Qian H, Xu W, Zhu W. Exosomes Derived from Akt-Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet-Derived Growth Factor D. Stem Cells Transl Med. 2017 Jan;6(1):51-59. doi: 10.5966/sctm.2016-0038. Epub 2016 Sep 22. PMID: 28170176; PMCID: PMC5442756.

  13. Zhao Y, Wang X, Yang S, Song X, Sun N, Chen C, Zhang Y, Yao D, Huang J, Wang J, Zhang Y, Yang B. Kanglexin accelerates diabetic wound healing by promoting angiogenesis via FGFR1/ERK signaling. Biomed Pharmacother. 2020 Dec;132:110933. doi: 10.1016/j.biopha.2020.110933. Epub 2020 Oct 28. PMID: 33128943.

  14. Rahman HS, Tan BL, Othman HH, Chartrand MS, Pathak Y, Mohan S, Abdullah R, Alitheen NB. An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies. Biomed Res Int. 2020 Dec 10;2020:8857428. doi: 10.1155/2020/8857428. PMID: 33381591; PMCID: PMC7748901.

  15. Liu X, Yang Y, Guo X, Liu L, Wu K, Yu M. The Antiangiogenesis Effect of Pirfenidone in Wound Healing In Vitro. J Ocul Pharmacol Ther. 2017 Nov;33(9):693-703. doi: 10.1089/jop.2017.0007. Epub 2017 Sep 21. PMID: 28933986.

  16. Jia W, Hu H, Li A, Deng H, Hogue CL, Mauro JC, Zhang C, Fu Q. Glass- activated regeneration of volumetric muscle loss. Acta Biomater. 2020 Feb;103:306-317. doi: 10.1016/j.actbio.2019.12.007. Epub 2019 Dec 9. PMID: 31830584.

  17. Zhang Y, Pan Y, Liu Y, Li X, Tang L, Duan M, Li J, Zhang G. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition. Stem Cell Res Ther. 2021 Aug 3;12(1):434. doi: 10.1186/s13287-021-02517-0. PMID: 34344478; PMCID: PMC8336384.

  18. Gabrielyan A, Quade M, Gelinsky M, Rösen-Wolff A. IL-11 and soluble VCAM-1 are important components of Hypoxia Conditioned Media and crucial for Mesenchymal Stromal Cells attraction. Stem Cell Res. 2020 May;45:101814. doi: 10.1016/j.scr.2020.101814. Epub 2020 Apr 20. PMID: 32334367.

  19. Dai F, Gao L, Zhao Y, Wang C, Xie S. Farrerol inhibited angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway. Phytomedicine. 2016 Jun 15;23(7):686-93. doi: 10.1016/j.phymed.2016.03.008. Epub 2016 Apr 9. PMID: 27235707.

  20. Chen Z, Haus JM, Chen L, Wu SC, Urao N, Koh TJ, Minshall RD. CCL28-induced CCR10/eNOS interaction in angiogenesis and skin wound healing. FASEB J. 2020 Apr;34(4):5838-5850. doi: 10.1096/fj.201902060R. Epub 2020 Mar 2. PMID: 32124475; PMCID: PMC7136142.

  21. Jian J, Zheng Z, Zhang K, Rackohn TM, Hsu C, Levin A, Enjamuri DR, Zhang X, Ting K, Soo C. Fibromodulin promoted in vitro and in vivo angiogenesis. Biochem Biophys Res Commun. 2013 Jul 5;436(3):530-535. doi: 10.1016/j.bbrc.2013.06.005. Epub 2013 Jun 11. PMID: 23770359; PMCID: PMC4007216.

  22. Berrich M, Kieda C, Grillon C, Monteil M, Lamerant N, Gavard J, Boulouis HJ, Haddad N. Differential effects of Bartonella henselae on human and feline macro- and micro-vascular endothelial cells. PLoS One. 2011;6(5):e20204. doi: 10.1371/journal.pone.0020204. Epub 2011 May 27. PMID: 21637717; PMCID: PMC3103534.

  23. Kim DW, Jo YY, Garagiola U, Choi JY, Kang YJ, Oh JH, Kim SG. Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals. Int J Mol Sci. 2020 May 14;21(10):3473. doi: 10.3390/ijms21103473. PMID: 32423083; PMCID: PMC7279008.
  24. Pan L, Tang J, Liu H, Cheng B. Sympathetic nerves: How do they affect angiogenesis, particularly during wound healing of soft tissues? Clin Hemorheol Microcirc. 2016;62(2):181-91. doi: 10.3233/CH-152019. PMID: 26484721.

  25. Li H, He J, Yu H, Green CR, Chang J. Bioglass promotes wound healing by affecting gap junction connexin 43 mediated endothelial cell behavior. Biomaterials. 2016 Apr;84:64-75. doi: 10.1016/j.biomaterials.2016.01.033. Epub 2016 Jan 19. PMID: 26821121.

  26. Abate M, Pisanti S, Caputo M, Citro M, Vecchione C, Martinelli R. 3-Hydroxytyrosol Promotes Angiogenesis In Vitro by Stimulating Endothelial Cell Migration. Int J Mol Sci. 2020 May 22;21(10):3657. doi: 10.3390/ijms21103657. PMID: 32455901; PMCID: PMC7279499.

  27. Boucher JM, Clark RP, Chong DC, Citrin KM, Wylie LA, Bautch VL. Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis. Nat Commun. 2017 Jun 7;8:15699. doi: 10.1038/ncomms15699. PMID: 28589930; PMCID: PMC5467243.

  28. Zhong C, Li P, Argade S, Liu L, Chilla’ A, Liang W, Xin H, Eliceiri B, Choudhury B, Ferrara N. Inhibition of protein glycosylation is a novel pro- angiogenic strategy that acts via activation of stress pathways. Nat Commun. 2020 Dec 10;11(1):6330. doi: 10.1038/s41467-020-20108-0. PMID: 33303737; PMCID: PMC7730427.

  29. Yu Y, Chen R, Sun Y, Pan Y, Tang W, Zhang S, Cao L, Yuan Y, Wang J, Liu C. Manipulation of VEGF-induced angiogenesis by 2-N, 6-O-sulfated chitosan. Acta Biomater. 2018 Apr 15;71:510-521. doi: 10.1016/j.actbio.2018.02.031. Epub 2018 Mar 12. PMID: 29501817.

  30. Cunha F, Rajnicek AM, McCaig CD. Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells. J Vasc Res. 2019;56(1):39-53. doi: 10.1159/000495311. Epub 2019 Apr 17. PMID: 30995642.

  31. Cunha F, Rajnicek AM, McCaig CD. Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells. J Vasc Res. 2019;56(1):39-53. doi: 10.1159/000495311. Epub 2019 Apr 17. PMID: 30995642.

  32. Cunha F, Rajnicek AM, McCaig CD. Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells. J Vasc Res. 2019;56(1):39-53. doi: 10.1159/000495311. Epub 2019 Apr 17. PMID: 30995642.

  1. Cunha F, Rajnicek AM, McCaig CD. Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells. J Vasc Res. 2019;56(1):39-53. doi: 10.1159/000495311. Epub 2019 Apr 17. PMID: 30995642.

  2. Yang R, Wang J, Zhou Z, Qi S, Ruan S, Lin Z, Xin Q, Lin Y, Chen X, Xie J. Curcumin promotes burn wound healing in mice by upregulating caveolin-1 in epidermal stem cells. Phytother Res. 2019 Feb;33(2):422-430. doi: 10.1002/ptr.6238. Epub 2018 Nov 20. PMID: 30461085.

  3. Feng X, Zhang X, Li S, Zheng Y, Shi X, Li F, Guo S, Yang J. Preparation of aminated fish scale collagen and oxidized sodium alginate hybrid hydrogel for enhanced full-thickness wound healing. Int J Biol Macromol. 2020 Dec 1;164:626-637. doi: 10.1016/j.ijbiomac.2020.07.058. Epub 2020 Jul 12. PMID: 32668308.
  4. Zhang Q, Zhou M, Wu X, Li Z, Liu B, Gao W, Yue J, Liu T. Promoting therapeutic angiogenesis of focal cerebral ischemia using thrombospondin-4 (TSP4) gene-modified bone marrow stromal cells (BMSCs) in a rat model. J Transl Med. 2019 Apr 4;17(1):111. doi: 10.1186/s12967-019-1845-z. PMID: 30947736; PMCID: PMC6449913.

  5. Radmanesh F, Abandansari HS, Pahlavan S, Alikhani M, Karimi M, Rajabi S, Kazemi B, Baharvand H. Optimization of miRNA delivery by using a polymeric conjugate based on deoxycholic acid-modified polyethylenimine. Int J Pharm. 2019 Jun 30;565:391-408. doi: 10.1016/j.ijpharm.2019.05.009. Epub 2019 May 11. PMID: 31085260.

  6. Reine TM, Vuong TT, Rutkovskiy A, Meen AJ, Vaage J, Jenssen TG, Kolset SO. Serglycin in Quiescent and Proliferating Primary Endothelial Cells. PLoS One. 2015 Dec 22;10(12):e0145584. doi: 10.1371/journal.pone.0145584. PMID: 26694746; PMCID: PMC4687888.

  7. Xu M, Hua Y, Qi Y, Meng G, Yang S. Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement. Exp Dermatol. 2019 Jul;28(7):776-785. doi: 10.1111/exd.13930. Epub 2019 May 15. PMID: 30927279.

  8. Wu ZB, Cai L, Lin SJ, Leng ZG, Guo YH, Yang WL, Chu YW, Yang SH, Zhao WG. Heat Shock Protein 47 Promotes Glioma Angiogenesis. Brain Pathol. 2016 Jan;26(1):31-42. doi: 10.1111/bpa.12256. Epub 2015 May 7. PMID: 25758142.

  9. Jiang S, Li Y, Lin T, Yuan L, Li Y, Wu S, Xia L, Shen H, Lu J. IL-35 Inhibits Angiogenesis through VEGF/Ang2/Tie2 Pathway in Rheumatoid Arthritis. Cell Physiol Biochem. 2016;40(5):1105-1116. doi: 10.1159/000453165. Epub 2016 Dec 14. PMID: 27960151.

  10. Sáez T, de Vos P, Kuipers J, Sobrevia L, Faas MM. Fetoplacental endothelial exosomes modulate high d-glucose-induced endothelial dysfunction. Placenta. 2018 Jun;66:26-35. doi: 10.1016/j.placenta.2018.04.010. Epub 2018 Apr 21. PMID: 29884299.

  11. Hu Q, Guo Y, Zhang T, Feng J, Wang J, Dong X, Chen Y, Nie R, Feng Z, Huang Y, Deng M, Ke X. Importance of β2AR elevation for re- endothelialization capacity mediated by late endothelial progenitor cells in hypertensive patients. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H867-H880. doi: 10.1152/ajpheart.00596.2020. Epub 2020 Dec 24. PMID: 33356961.

  12. Sun G, Li G, Li D, Huang W, Zhang R, Zhang H, Duan Y, Wang B. hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation. Mater Sci Eng C Mater Biol Appl. 2018 Aug 1;89:194-204. doi: 10.1016/j.msec.2018.04.006. Epub 2018 Apr 10. PMID: 29752089.

  13. Zhou X, Patel D, Sen S, Shanmugam V, Sidawy A, Mishra L, Nguyen BN. Poly- ADP-ribose polymerase inhibition enhances ischemic and diabetic wound healing by promoting angiogenesis. J Vasc Surg. 2017 Apr;65(4):1161-1169. doi: 10.1016/j.jvs.2016.03.407. Epub 2016 Jun 8. PMID: 27288104.

  14. Tzoneva R, Uzunova V, Apostolova S, Krüger-Genge A, Neffe AT, Jung F, Lendlein A. Angiogenic potential of endothelial and tumor cells seeded on gelatin-based hydrogels in response to electrical stimulations. Clin Hemorheol Microcirc. 2016;64(4):941-949. doi: 10.3233/CH-168040. PMID: 27792001.Feng Y, Zhan F, Zhong Y, Tan B. Effects of human umbilical cord mesenchymal stem cells derived from exosomes on migration ability of endometrial glandular epithelial cells. Mol Med Rep. 2020 Aug;22(2):715-722. doi: 10.3892/mmr.2020.11137. Epub 2020 May 7. PMID: 32626977; PMCID: PMC7339775.

  15. He L, Tu HJ, He WF, Guo LL, Yu SX, Li J, Wu Q, Li J. Lentiviral-mediated overexpression of homeobox A4 by human umbilical cord mesenchymal stem cells repairs full-thickness skin defects. Mol Med Rep. 2015 May;11(5):3517-22. doi: 10.3892/mmr.2015.3208. Epub 2015 Jan 16. PMID: 25592724.

  16. Tomioka H, Nakagami H, Tenma A, Saito Y, Kaga T, Kanamori T, Tamura N, Tomono K, Kaneda Y, Morishita R. Novel anti-microbial peptide SR-0379 accelerates wound healing via the PI3 kinase/Akt/mTOR pathway. PLoS One. 2014 Mar 27;9(3):e92597. doi: 10.1371/journal.pone.0092597. PMID: 24675668; PMCID: PMC3968008.

  17. Maltaneri RE, Schiappacasse A, Chamorro ME, Nesse AB, Vittori DC. Aquaporin-1 plays a key role in erythropoietin-induced endothelial cell migration. Biochim Biophys Acta Mol Cell Res. 2020 Jan;1867(1):118569. doi: 10.1016/j.bbamcr.2019.118569. Epub 2019 Oct 30. PMID: 31676353.

  18. Park JY, Shin MS, Hwang GS, Yamabe N, Yoo JE, Kang KS, Kim JC, Lee JG, Ham J, Lee HL. Beneficial Effects of Deoxyshikonin on Delayed Wound Healing in Diabetic Mice. Int J Mol Sci. 2018 Nov 20;19(11):3660. doi: 10.3390/ijms19113660. PMID: 30463303; PMCID: PMC6274849.

  19. Guo J, Linetsky M, Yu AO, Zhang L, Howell SJ, Folkwein HJ, Wang H, Salomon RG. 4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways. Chem Res Toxicol. 2016 Dec 19;29(12):2125-2135. doi: 10.1021/acs.chemrestox.6b00233. Epub 2016 Nov 11. PMID: 27806561; PMCID: PMC5349710.

  20. Futakuchi A, Inoue T, Fujimoto T, Kuroda U, Inoue-Mochita M, Takahashi E, Ohira S, Tanihara H. Molecular Mechanisms Underlying the Filtration Bleb- Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA). Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2421-2429. doi: 10.1167/iovs.16-21403. PMID: 28448670.

  21. Passaretti F, Tia M, D’Esposito V, De Pascale M, Del Corso M, Sepulveres R, Liguoro D, Valentino R, Beguinot F, Formisano P, Sammartino G. Growth-promoting action and growth factor release by different platelet derivatives. Platelets. 2014;25(4):252-6. doi: 10.3109/09537104.2013.809060. Epub 2013 Jul 15. PMID: 23855408.

  22. Inglis S, Christensen D, Wilson DI, Kanczler JM, Oreffo RO. Human endothelial and foetal femur-derived stem cell co-cultures modulate osteogenesis and angiogenesis. Stem Cell Res Ther. 2016 Jan 18;7:13. doi: 10.1186/s13287-015-0270-3. PMID: 26781715; PMCID: PMC4717648.
  23. Ferreira AK, Freitas VM, Levy D, Ruiz JL, Bydlowski SP, Rici RE, Filho OM, Chierice GO, Maria DA. Anti-angiogenic and anti-metastatic activity of synthetic phosphoethanolamine. PLoS One. 2013;8(3):e57937. doi: 10.1371/journal.pone.0057937. Epub 2013 Mar 14. PMID: 23516420; PMCID: PMC3597720.

  24. Gärtner A, Pereira T, Alves MG, Armada-da-Silva PA, Amorim I, Gomes R, Ribeiro J, França ML, Lopes C, Carvalho RA, Socorro S, Oliveira PF, Porto B, Sousa R, Bombaci A, Ronchi G, Fregnan F, Varejão AS, Luís AL, Geuna S, Maurício AC. Use of poly(DL-lactide-ε-caprolactone) membranes and mesenchymal stem cells from the Wharton’s jelly of the umbilical cord for promoting nerve regeneration in axonotmesis: in vitro and in vivo analysis. Differentiation. 2012 Dec;84(5):355-65. doi: 10.1016/j.diff.2012.10.001. Epub 2012 Nov 7. Erratum in: Differentiation. 2013 Feb;85(3):119. Alves, Marco G [added];Carvalho, Rui A [added];Socorro, S [added]; Oliveira, Pedro F [added]. PMID: 23142731.

  25. Oh SY, Lee SJ, Jung YH, Lee HJ, Han HJ. Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation. Cell Death Dis. 2015 May 7;6(5):e1750. doi: 10.1038/cddis.2015.114. PMID: 25950480; PMCID: PMC4669694.

  26. Teramatsu Y, Maeda H, Sugii H, Tomokiyo A, Hamano S, Wada N, Yuda A, Yamamoto N, Koori K, Akamine A. Expression and effects of epidermal growth factor on human periodontal ligament cells. Cell Tissue Res. 2014 Sep;357(3):633-43. doi: 10.1007/s00441-014-1877-x. Epub 2014 May 22. PMID: 24850273.

  27. Huang L, Wong YP, Gu H, Cai YJ, Ho Y, Wang CC, Leung TY, Burd A. Stem cell- like properties of human umbilical cord lining epithelial cells and the potential for epidermal reconstitution. Cytotherapy. 2011 Feb;13(2):145-55. doi: 10.3109/14653249.2010.509578. Epub 2010 Aug 24. PMID: 20735166.

  28. Ouyang Z, Tan T, Zhang X, Wan J, Zhou Y, Jiang G, Yang D, Liu T. LncRNA ENST00000563492 promoting the osteogenesis-angiogenesis coupling process in bone mesenchymal stem cells (BMSCs) by functions as a ceRNA for miR-205-5p. Cell Death Dis. 2020 Jun 25;11(6):486. doi: 10.1038/s41419-020-2689-4. PMID: 32587236; PMCID: PMC7316863.

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  1. Zhang W, Shao C, Yu F, Chen J, Fu Y, Fan X. Y-27632 Promotes the Repair Effect of Umbilical Cord Blood-Derived Endothelial Progenitor Cells on Corneal Endothelial Wound Healing. Cornea. 2021 Feb 1;40(2):203-214. doi: 10.1097/ICO.0000000000002560. PMID: 33086282.

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Third party research (Regenerative)
Third party research
(Interstitium and Telocytes)
Third party research
(Technology Advancements)
Third party research (Fascia and Connective Tissue)
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  2. Zhu Y, Wang Y, Jia Y, Xu J, Chai Y. Roxadustat promotes angiogenesis through HIF-1α/VEGF/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats. Wound Repair Regen. 2019 Jul;27(4):324-334. doi: 10.1111/wrr.12708. Epub 2019 Feb 28. PMID: 30817065.

  3. Huang X, Liang P, Jiang B, Zhang P, Yu W, Duan M, Guo L, Cui X, Huang M, Huang X. Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis. Life Sci. 2020 Oct 15;259:118246. doi: 10.1016/j.lfs.2020.118246. Epub 2020 Aug 10. PMID: 32791151.

  4. Bullard JD, Lei J, Lim JJ, Massee M, Fallon AM, Koob TJ. Evaluation of dehydrated human umbilical cord biological properties for wound care and soft tissue healing. J Biomed Mater Res B Appl Biomater. 2019 May;107(4):1035-1046. doi: 10.1002/jbm.b.34196. Epub 2018 Sep 10. PMID: 30199609; PMCID: PMC6585686.

  5. Hsieh L, Nugent D. Factor XIII deficiency. Haemophilia. 2008 Nov;14(6):1190-200. doi: 10.1111/j.1365-2516.2008.01857.x. PMID: 19141159.

  6. Gaebel R, Furlani D, Sorg H, Polchow B, Frank J, Bieback K, Wang W, Klopsch C, Ong LL, Li W, Ma N, Steinhoff G. Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration. PLoS One. 2011 Feb 10;6(2):e15652. doi: 10.1371/journal.pone.0015652. PMID: 21347366; PMCID: PMC3037376.

  7. Yan ZJ, Wang D, Ye Z, Fan T, Wu G, Deng L, Yang L, Li B, Liu J, Ma T, Dong C, Li ZT, Xiao L, Wang Y, Wang W, Hou JL. Artificial Aquaporin That Restores Wound Healing of Impaired Cells. J Am Chem Soc. 2020 Sep 16;142(37):15638-15643. doi: 10.1021/jacs.0c00601. Epub 2020 Sep 3. PMID: 32876439.

  8. Mouritzen MV, Andrea A, Qvist K, Poulsen SS, Jenssen H. Immunomodulatory potential of Nisin A with application in wound healing. Wound Repair Regen. 2019 Nov;27(6):650-660. doi: 10.1111/wrr.12743. Epub 2019 Jul 9. PMID: 31287619.

  9. Wang TY, Wang W, Li FF, Chen YC, Jiang D, Chen YD, Yang H, Liu L, Lu M, Sun JS, Gu DM, Wang J, Wang AP. Maggot excretions/secretions promote diabetic wound angiogenesis via miR18a/19a – TSP-1 axis. Diabetes Res Clin Pract. 2020 Jul;165:108140. doi: 10.1016/j.diabres.2020.108140. Epub 2020 Apr 8. PMID: 32277954.

  10. Feng Y, Zhan F, Zhong Y, Tan B. Effects of human umbilical cord mesenchymal stem cells derived from exosomes on migration ability of endometrial glandular epithelial cells. Mol Med Rep. 2020 Aug;22(2):715-722. doi: 10.3892/mmr.2020.11137. Epub 2020 May 7. PMID: 32626977; PMCID: PMC7339775.

  11. Qi WY, Gao XM, Ma ZY, Xia CL, Xu HM. Antiangiogenic activity of terpenoids from Euphorbia neriifolia Linn. Bioorg Chem. 2020 Mar;96:103536. doi: 10.1016/j.bioorg.2019.103536. Epub 2019 Dec 28. PMID: 31972463.

  12. Ma J, Zhao Y, Sun L, Sun X, Zhao X, Sun X, Qian H, Xu W, Zhu W. Exosomes Derived from Akt-Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet-Derived Growth Factor D. Stem Cells Transl Med. 2017 Jan;6(1):51-59. doi: 10.5966/sctm.2016-0038. Epub 2016 Sep 22. PMID: 28170176; PMCID: PMC5442756.

  13. Zhao Y, Wang X, Yang S, Song X, Sun N, Chen C, Zhang Y, Yao D, Huang J, Wang J, Zhang Y, Yang B. Kanglexin accelerates diabetic wound healing by promoting angiogenesis via FGFR1/ERK signaling. Biomed Pharmacother. 2020 Dec;132:110933. doi: 10.1016/j.biopha.2020.110933. Epub 2020 Oct 28. PMID: 33128943.

  14. Rahman HS, Tan BL, Othman HH, Chartrand MS, Pathak Y, Mohan S, Abdullah R, Alitheen NB. An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies. Biomed Res Int. 2020 Dec 10;2020:8857428. doi: 10.1155/2020/8857428. PMID: 33381591; PMCID: PMC7748901.

  15. Liu X, Yang Y, Guo X, Liu L, Wu K, Yu M. The Antiangiogenesis Effect of Pirfenidone in Wound Healing In Vitro. J Ocul Pharmacol Ther. 2017 Nov;33(9):693-703. doi: 10.1089/jop.2017.0007. Epub 2017 Sep 21. PMID: 28933986.

  16. Jia W, Hu H, Li A, Deng H, Hogue CL, Mauro JC, Zhang C, Fu Q. Glass- activated regeneration of volumetric muscle loss. Acta Biomater. 2020 Feb;103:306-317. doi: 10.1016/j.actbio.2019.12.007. Epub 2019 Dec 9. PMID: 31830584.

  17. Zhang Y, Pan Y, Liu Y, Li X, Tang L, Duan M, Li J, Zhang G. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition. Stem Cell Res Ther. 2021 Aug 3;12(1):434. doi: 10.1186/s13287-021-02517-0. PMID: 34344478; PMCID: PMC8336384.

  18. Gabrielyan A, Quade M, Gelinsky M, Rösen-Wolff A. IL-11 and soluble VCAM-1 are important components of Hypoxia Conditioned Media and crucial for Mesenchymal Stromal Cells attraction. Stem Cell Res. 2020 May;45:101814. doi: 10.1016/j.scr.2020.101814. Epub 2020 Apr 20. PMID: 32334367.

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  23. Kim DW, Jo YY, Garagiola U, Choi JY, Kang YJ, Oh JH, Kim SG. Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals. Int J Mol Sci. 2020 May 14;21(10):3473. doi: 10.3390/ijms21103473. PMID: 32423083; PMCID: PMC7279008.
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  25. Li H, He J, Yu H, Green CR, Chang J. Bioglass promotes wound healing by affecting gap junction connexin 43 mediated endothelial cell behavior. Biomaterials. 2016 Apr;84:64-75. doi: 10.1016/j.biomaterials.2016.01.033. Epub 2016 Jan 19. PMID: 26821121.

  26. Abate M, Pisanti S, Caputo M, Citro M, Vecchione C, Martinelli R. 3-Hydroxytyrosol Promotes Angiogenesis In Vitro by Stimulating Endothelial Cell Migration. Int J Mol Sci. 2020 May 22;21(10):3657. doi: 10.3390/ijms21103657. PMID: 32455901; PMCID: PMC7279499.

  27. Boucher JM, Clark RP, Chong DC, Citrin KM, Wylie LA, Bautch VL. Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis. Nat Commun. 2017 Jun 7;8:15699. doi: 10.1038/ncomms15699. PMID: 28589930; PMCID: PMC5467243.

  28. Zhong C, Li P, Argade S, Liu L, Chilla’ A, Liang W, Xin H, Eliceiri B, Choudhury B, Ferrara N. Inhibition of protein glycosylation is a novel pro- angiogenic strategy that acts via activation of stress pathways. Nat Commun. 2020 Dec 10;11(1):6330. doi: 10.1038/s41467-020-20108-0. PMID: 33303737; PMCID: PMC7730427.

  29. Yu Y, Chen R, Sun Y, Pan Y, Tang W, Zhang S, Cao L, Yuan Y, Wang J, Liu C. Manipulation of VEGF-induced angiogenesis by 2-N, 6-O-sulfated chitosan. Acta Biomater. 2018 Apr 15;71:510-521. doi: 10.1016/j.actbio.2018.02.031. Epub 2018 Mar 12. PMID: 29501817.

  30. Cunha F, Rajnicek AM, McCaig CD. Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells. J Vasc Res. 2019;56(1):39-53. doi: 10.1159/000495311. Epub 2019 Apr 17. PMID: 30995642.

  31. Cunha F, Rajnicek AM, McCaig CD. Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells. J Vasc Res. 2019;56(1):39-53. doi: 10.1159/000495311. Epub 2019 Apr 17. PMID: 30995642.

  32. Cunha F, Rajnicek AM, McCaig CD. Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells. J Vasc Res. 2019;56(1):39-53. doi: 10.1159/000495311. Epub 2019 Apr 17. PMID: 30995642.

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  2. Yang R, Wang J, Zhou Z, Qi S, Ruan S, Lin Z, Xin Q, Lin Y, Chen X, Xie J. Curcumin promotes burn wound healing in mice by upregulating caveolin-1 in epidermal stem cells. Phytother Res. 2019 Feb;33(2):422-430. doi: 10.1002/ptr.6238. Epub 2018 Nov 20. PMID: 30461085.

  3. Feng X, Zhang X, Li S, Zheng Y, Shi X, Li F, Guo S, Yang J. Preparation of aminated fish scale collagen and oxidized sodium alginate hybrid hydrogel for enhanced full-thickness wound healing. Int J Biol Macromol. 2020 Dec 1;164:626-637. doi: 10.1016/j.ijbiomac.2020.07.058. Epub 2020 Jul 12. PMID: 32668308.
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  5. Radmanesh F, Abandansari HS, Pahlavan S, Alikhani M, Karimi M, Rajabi S, Kazemi B, Baharvand H. Optimization of miRNA delivery by using a polymeric conjugate based on deoxycholic acid-modified polyethylenimine. Int J Pharm. 2019 Jun 30;565:391-408. doi: 10.1016/j.ijpharm.2019.05.009. Epub 2019 May 11. PMID: 31085260.

  6. Reine TM, Vuong TT, Rutkovskiy A, Meen AJ, Vaage J, Jenssen TG, Kolset SO. Serglycin in Quiescent and Proliferating Primary Endothelial Cells. PLoS One. 2015 Dec 22;10(12):e0145584. doi: 10.1371/journal.pone.0145584. PMID: 26694746; PMCID: PMC4687888.

  7. Xu M, Hua Y, Qi Y, Meng G, Yang S. Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement. Exp Dermatol. 2019 Jul;28(7):776-785. doi: 10.1111/exd.13930. Epub 2019 May 15. PMID: 30927279.

  8. Wu ZB, Cai L, Lin SJ, Leng ZG, Guo YH, Yang WL, Chu YW, Yang SH, Zhao WG. Heat Shock Protein 47 Promotes Glioma Angiogenesis. Brain Pathol. 2016 Jan;26(1):31-42. doi: 10.1111/bpa.12256. Epub 2015 May 7. PMID: 25758142.

  9. Jiang S, Li Y, Lin T, Yuan L, Li Y, Wu S, Xia L, Shen H, Lu J. IL-35 Inhibits Angiogenesis through VEGF/Ang2/Tie2 Pathway in Rheumatoid Arthritis. Cell Physiol Biochem. 2016;40(5):1105-1116. doi: 10.1159/000453165. Epub 2016 Dec 14. PMID: 27960151.

  10. Sáez T, de Vos P, Kuipers J, Sobrevia L, Faas MM. Fetoplacental endothelial exosomes modulate high d-glucose-induced endothelial dysfunction. Placenta. 2018 Jun;66:26-35. doi: 10.1016/j.placenta.2018.04.010. Epub 2018 Apr 21. PMID: 29884299.

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  12. Sun G, Li G, Li D, Huang W, Zhang R, Zhang H, Duan Y, Wang B. hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation. Mater Sci Eng C Mater Biol Appl. 2018 Aug 1;89:194-204. doi: 10.1016/j.msec.2018.04.006. Epub 2018 Apr 10. PMID: 29752089.

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  1. Zhang W, Shao C, Yu F, Chen J, Fu Y, Fan X. Y-27632 Promotes the Repair Effect of Umbilical Cord Blood-Derived Endothelial Progenitor Cells on Corneal Endothelial Wound Healing. Cornea. 2021 Feb 1;40(2):203-214. doi: 10.1097/ICO.0000000000002560. PMID: 33086282.

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